anti-p53 phospho-S46 antibody monoclonal(#36)

Code:71-115

p53 mutants are found in more than half of human cancers and are considered as the most important human cancer related gene. p53 is detected at 53kD position by electrophoresis and is composed of 393 amino acids. In the unstressed normal cells the p53 level is low and it is inactive. However with stress especially with DNA damage it is activated to promote arrest of cell cycle and repair of DNA damage or induction of apoptosis. The functions of p53 are regulated by phosphorylation of serine and threonine and acetylation of lysine at various sites in the molecule. Among the phosphorylation sites Ser46 is phosphorylated when DNA damage is so severe as to become unrepairable which leads to apoptosis by activating transcription of proapoptotic genes such as p53AIPI As to the kinase of phosphorylation of Ser46 involvement of DYRK2 and ATM have been implicated.

anti-p53 p-Ser315(human）antibody、monoclonal(#18)

Code:71-117

p53 mutants are found in more than half of human cancers and are considered as the most important human cancer related gene. p53 is detected at 53kD position by electrophoresis and is composed of 393 amino acids. In the unstressed normal cells the p53 level is low and it is inactive. However with stress especially with DNA damage it is activated to promote arrest of cell cycle and repair of DNA damage or induction of apoptosis. The functions and stability of p53 are regulated by phosphorylation of serine and threonine and acetylation of lysine at various sites in the molecule.
Ser315 is phosphorylated by aurora kinase and cycline-dependent kinases when cells are subjected to stress such as DNA damage and microtubule disruption by nocodazole (ref 1 2 & 3). However the effect of the phosphorylation on the function of p53 is mostly unknown.
This product is the purified IgG fraction obtained from serum-free culture medium of mouse hybridoma (clone #18) which produces monoclonal antibody that specifically recognizes human p53 protein with phospholyrated Ser315.

anti-p53 Ac-K382(human)antibodymonoclonal(2B7E4)

Code:71-133

p53 mutants are found in more than half of human cancers and are considered as the most important human cancer related gene. p53 is detected at 53kD position by electrophoresis and is composed of 393 amino acids. In the unstressed normal cells the p53 level is low and it is inactive. However with stress especially with DNA damage it is activated to promote arrest of cell cycle and repair of DNA damage or induction of apoptosis. The functions and stability of p53 are regulated by phosphorylation of serine and threonine and acetylation of lysine at various sites in the molecule.
Acetylation of lysine 382 (acetyl-K382) of p53 occurs after DNA damage and is catalyzed by the p300/CBP acetyltransferase which stabilizes p53 proten (ref 1).