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code:71-023
Key Words: GTP-Binding Protein mTORC1 TOR signaling cascade
Function: Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids
Molecular mass: 44224 with 399 amino acids. Rag C forms a functional complex with Rag A and Rag B.
Cellular localization: Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus depending on the bound nucleotide state of associated RagA.
Post-translational modification: Acetylation and phosphorylation
Applications
1) Western blotting ( 1000~ 2000 folds dilution)
2) Immunofluorescence staining (1/100~1/500)
Not tested for other applications
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