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Code:63-135
Schizosaccharomyces pombe Ppa2 is a type 2A-like serine/threonine-protein phosphatase catalytic subunit whose polypeptide sequence has ~80% identity to those of mammalian type 2A phosphatases. Ppa2 determines the sensitivity to okadaic acid which is an inhibitor of protein serine/threonine phosphatases. The loss of the ppa2 gene causes cells to be hypersensitive to the okadaic acid. Ppa2 plays important roles in cell cycle control. It may be involved in controlling the entry into mitosis possibly acting as an inhibitor (ref.1). Ppa2 is abundant in the cytoplasm in contrast to the type 1-like phosphatase Dis2 which is enriched in the nucleus. Thus Ppa2 may perform major functions outside the nucleus.
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