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73-062
Product:anti-SPACA1 antibody. Rabbit polyclonal IgG fraction 1 mg/ml in PBS 50% glycerol
Reactivity: Mouse
Application: WB IF
Immunogen: C-terminal peptide of mouse SPACA1 protein QSPTDIPVHEDDALSEWNEconjugated with KLH
Function: SPACA1 is a membrane protein that localizes in the equatorial segment of spermatozoa in mammals and is reported to function in sperm-egg fusion. Disruption of Spaca1 led to the disappearance of the nuclear plate a dense lining of the nuclear envelope facing the inner acrosomal membrane. This coincided with the failure of acrosomal expansion during spermiogenesis and resulted in the degeneration and disappearance of the acrosome in mature spermatozoa. SPACA1-deficient male mice are infertile.
Molecular mass: 33343 Da with 611 amino acids
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